A Rapid and Sensitive Strip-Based Quick Test for Nerve Agents Tabun, Sarin, and Soman Using BODIPY-Modified Silica Materials

Chemistry. 2016 Aug 1;22(32):11138-42. doi: 10.1002/chem.201601269. Epub 2016 May 30.

Abstract

Test strips that in combination with a portable fluorescence reader or digital camera can rapidly and selectively detect chemical warfare agents (CWAs) such as Tabun (GA), Sarin (GB), and Soman (GD) and their simulants in the gas phase have been developed. The strips contain spots of a hybrid indicator material consisting of a fluorescent BODIPY indicator covalently anchored into the channels of mesoporous SBA silica microparticles. The fluorescence quenching response allows the sensitive detection of CWAs in the μg m(-3) range in a few seconds.

Keywords: chemical warfare agents; fluorescence; hybrid sensor materials; nerve gases; test strip analysis.

MeSH terms

  • Boron Compounds / chemistry*
  • Chemical Warfare Agents / analysis
  • Chemical Warfare Agents / chemistry*
  • Nerve Agents / analysis
  • Nerve Agents / chemistry*
  • Organophosphates / analysis
  • Organophosphates / chemistry*
  • Prothrombin Time / methods*
  • Sarin / analysis
  • Sarin / chemistry*
  • Silicon Dioxide / chemistry*
  • Soman / analysis
  • Soman / chemistry*

Substances

  • 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
  • Boron Compounds
  • Chemical Warfare Agents
  • Nerve Agents
  • Organophosphates
  • Silicon Dioxide
  • Soman
  • Sarin
  • tabun