The study aimed to investigate prevalence of modifiable risk factors of chronic non infection diseases among urban and rural residents in Karaganda region. The cross-sectional screening study of 1453 respondents' age 18 to 65 among the urban and rural population of the Karaganda region: 672 urban and 781 rural adult residents were included into the study. The screening stage included conducting survey using international questionnaires, anthropometry, arterial blood pressure, fasting plasma glucose and total cholesterol measurement. According study results the most common risk factors among residents of Saran town and Osakarovsky area included: hypercholesterolemia (46,2 % and 36,9 %, respectively), arterial hypertension (39,3 % and 32,2 %, respectively) and smoking (26,3 % and 19,5 % respectively). Frequency of active and passive smoking, hypertension, hypercholesterolemia, obesity and alcohol abuse 1.2-2.0 times higher compared in urban population in comparison rural population. These differences gave possibility to identify special groups need to management preventive targeted measures.