A Case Report of Antitubercular Drugs Induced Exanthematous Reaction Complicated by Acute Onset Levofloxacin Induced Toxic Epidermal Necrolysis (TEN)

Curr Drug Saf. 2018;13(1):41-43. doi: 10.2174/1574886311666160427104417.

Abstract

Background: We report a case of 25 years old male patient with antitubercular drugs induced exanthematous reaction and hepatotoxicity that was complicated by levofloxacin induced toxic epidermal necrolysis. The patient was allergic to ciprofloxacin and ofloxacin. Cross reactivity between ciprofloxacin and levofloxacin might be responsible for causing this reaction.

Conclusion: Issues of cross sensitivity should be kept in mind and the same class of drugs should strictly be avoided to prevent such complications.

Keywords: Exanthematous reaction; antituberculer drugs; cutaneous adverse reaction; hypersensitivity.; levofloxacin; toxic epidermal necrolysis.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adult
  • Antitubercular Agents / adverse effects*
  • Exanthema / chemically induced*
  • Exanthema / complications
  • Exanthema / diagnosis*
  • Humans
  • Levofloxacin / adverse effects*
  • Male
  • Stevens-Johnson Syndrome / complications
  • Stevens-Johnson Syndrome / diagnosis*

Substances

  • Antitubercular Agents
  • Levofloxacin