Solid Phase Synthesis of C-Terminal Boronic Acid Peptides

Org Lett. 2016 May 6;18(9):2016-9. doi: 10.1021/acs.orglett.6b00625. Epub 2016 Apr 22.

Abstract

Peptides and peptidomimetics with a C-terminal boronic acid group have prolific applications in numerous fields of research, but their synthetic accessibility remains problematic. A convenient, high yield synthesis of peptide-boronic acids on a solid support is described here, using commercially available 1-glycerol polystyrene resin. The method is compatible with Fmoc chemistry and offers a versatile approach to aryl and alkyl aminoboronic acids without additional purification steps.

Publication types

  • Research Support, Non-U.S. Gov't