Influences of mood on qualitative aspects of cognitive processing are examined within a semantic priming paradigm. The priming effect reflects the reduction of latency for a lexical decision task when a target word is presented in combination with an associatively related prime word. The effect was higher for subjects in whom positive affect had been induced than for a control group, if prime and target were high-associatively related. There was no effect of mood on priming for low-associatively related prime-target pairs. The results are interpreted in terms of a general facilitating influence of mood on spreading activation independent of the affective quality of the processed material.