Quorum Sensing Inhibitory Activity of Giganteone A from Myristica cinnamomea King against Escherichia coli Biosensors

Molecules. 2016 Mar 21;21(3):391. doi: 10.3390/molecules21030391.

Abstract

Malabaricones A-C (1-3) and giganteone A (4) were isolated from the bark of Myristica cinnamomea King. Their structures were elucidated and characterized by means of NMR and MS spectral analyses. These isolates were evaluated for their anti-quorum sensing activity using quorum sensing biosensors, namely Escherichia coli [pSB401] and Escherichia coli [pSB1075], whereby the potential of giganteone A (4) as a suitable anti-quorum sensing agent was demonstrated.

Keywords: Myristica cinnamomea King; Myristicaceae; acylphenols; anti-quorum sensing activity; dimeric acylphenols.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Biosensing Techniques*
  • Biphenyl Compounds / chemistry
  • Biphenyl Compounds / pharmacology*
  • Escherichia coli / drug effects
  • Escherichia coli / pathogenicity
  • Humans
  • Myristicaceae / chemistry
  • Pseudomonas aeruginosa / drug effects
  • Pseudomonas aeruginosa / pathogenicity
  • Quorum Sensing / drug effects*
  • Resorcinols / chemistry
  • Resorcinols / isolation & purification
  • Resorcinols / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Biphenyl Compounds
  • Resorcinols
  • giganteone A
  • malabaricone A