Abstract
Malabaricones A-C (1-3) and giganteone A (4) were isolated from the bark of Myristica cinnamomea King. Their structures were elucidated and characterized by means of NMR and MS spectral analyses. These isolates were evaluated for their anti-quorum sensing activity using quorum sensing biosensors, namely Escherichia coli [pSB401] and Escherichia coli [pSB1075], whereby the potential of giganteone A (4) as a suitable anti-quorum sensing agent was demonstrated.
Keywords:
Myristica cinnamomea King; Myristicaceae; acylphenols; anti-quorum sensing activity; dimeric acylphenols.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Biosensing Techniques*
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Biphenyl Compounds / chemistry
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Biphenyl Compounds / pharmacology*
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Escherichia coli / drug effects
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Escherichia coli / pathogenicity
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Humans
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Myristicaceae / chemistry
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / pathogenicity
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Quorum Sensing / drug effects*
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Resorcinols / chemistry
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Resorcinols / isolation & purification
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Resorcinols / pharmacology*
Substances
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Anti-Bacterial Agents
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Biphenyl Compounds
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Resorcinols
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giganteone A
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malabaricone A