CncRNAs: RNAs with both coding and non-coding roles in development

Abstract

RNAs are known to regulate diverse biological processes, either as protein-encoding molecules or as non-coding RNAs. However, a third class that comprises RNAs endowed with both protein coding and non-coding functions has recently emerged. Such bi-functional 'coding and non-coding RNAs' (cncRNAs) have been shown to play important roles in distinct developmental processes in plants and animals. Here, we discuss key examples of cncRNAs and review their roles, regulation and mechanisms of action during development.

Keywords: Bifunctional RNA; CncRNAs; Coding RNA; Development; Non-coding RNA; Regulatory RNA.