Abstract
One new alkaloid consanguine B (1), together with 10 known alkaloids (2-11), were isolated from ethanol extract of the branches and leaves of Polyalthia obliqua Hook.f. & Thomson collected in the Hainan Province, China. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. All compounds were evaluated for their cytotoxic activities. Compound 1 showed weak cytotoxic activities against Hela and MCF-7 human cancer cell lines.
Keywords:
Polyalthia oblique; alkaloid; cytotoxic activities.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification
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Alkaloids / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Berberine / chemistry
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Berberine Alkaloids / isolation & purification
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Berberine Alkaloids / pharmacology
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China
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Drug Screening Assays, Antitumor
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HeLa Cells / drug effects
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Humans
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MCF-7 Cells / drug effects
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Molecular Structure
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Plant Extracts / chemistry
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Plant Leaves / chemistry
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Polyalthia / chemistry*
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Berberine Alkaloids
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Plant Extracts
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consanguine B
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Berberine