[1-8-NαC]-Zanriorb A1, a Proapoptotic Orbitide from Leaves of Zanthoxylum riedelianum

J Nat Prod. 2016 May 27;79(5):1454-8. doi: 10.1021/acs.jnatprod.5b00177. Epub 2016 Apr 15.

Abstract

A new orbitide named [1-8-NαC]-zanriorb A1 (1) was isolated and characterized from the leaves of Zanthoxylum riedelianum using NMR and mass spectrometry. The absolute configuration of the amino acids was determined using Marfey's method on the acid hydrolysates. Compound 1 induced cell death by apoptosis in Jurkat leukemia T cells (IC50 218 nM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis / drug effects*
  • Brazil
  • DNA / analysis
  • Humans
  • Jurkat Cells
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification*
  • Peptides, Cyclic / pharmacology
  • Plant Leaves / chemistry*
  • Zanthoxylum / chemistry*

Substances

  • (1-8-NαC)-zanriorb A1
  • Peptides, Cyclic
  • DNA