The human bladder cancer (BC) diagnostics is being improvised every day for the better management and efficient diagnosis. The primary aim of all these innovations is to accomplish timely treatment and planning of BC patients. Diagnostic approaches involved both invasive as well as non-invasive methods, wherein; the extent of the spread of carcinogenesis is the deciding factor. The latest in the upcoming techniques is the utilization of principles of immunology for better and highly specific diagnosis. The present review article will be focused on the latest diagnostic methods for the better diagnosis of BC like utilization of tumor-infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs) BTA (bladder tumor antigen) etc. for the early BC diagnosis.