Circumferential resection margins and perineal complications after neoadjuvant long-course chemoradiotherapy followed by extralevator abdominoperineal excision of the rectum: Five years of activity at a single institution

J Surg Oncol. 2016 Jul;114(1):86-90. doi: 10.1002/jso.24257. Epub 2016 Apr 13.

Abstract

Background: Prone extralevator abdominoperineal excision of the rectum (ELAPE) has been introduced to improve the circumferential resection margins (CRM) compared with traditional APER.

Objective: We present short-term results achieved with prone ELAPE preceded by neoadjuvant chemoradiotherapy during the last 5 years of activity.

Design: A retrospective review was conducted.

Settings and patients: Prone ELAPE operations performed between September 2010 and August 2014 at Leicester Royal Infirmary preceded by neoadjuvant chemoradiotherapy.

Interventions and main outcome measures: Data regarding demographics, staging, neoadjuvant therapies, intraoperative perforations, and perineal complications were collected.

Results: Seventy-two patients were included. Pretreatment radiological T4 were 25.0%, histological T4 2.8%. Intraoperative perforations occurred in 2.8%, CRM was involved in 11.1%. Perineal complications consisted of superficial wound infections (20.8%), full thickness dehiscences (16.7%), hematomas (9.7%), pelvic collections (6.9%), and perineal hernias (5.6%).

Conclusions: In our experience, prone ELAPE preceded by long-course chemoradiotherapy has been successfully used in the last 5 years to resect low rectal tumors. Perineal wound complications rates are similar to those presented in series using direct perineal closures. J. Surg. Oncol. 2016;114:86-90. © 2016 Wiley Periodicals, Inc.

Keywords: circumferential margin; extralevator abdominoperineal resection; long-course chemoradiotherapy.

MeSH terms

  • Abdomen / surgery
  • Adenocarcinoma / therapy*
  • Adult
  • Aged
  • Aged, 80 and over
  • Chemoradiotherapy, Adjuvant*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Margins of Excision*
  • Middle Aged
  • Neoadjuvant Therapy*
  • Perineum / pathology
  • Perineum / surgery
  • Postoperative Complications / diagnosis
  • Postoperative Complications / epidemiology*
  • Postoperative Complications / etiology
  • Rectal Neoplasms / therapy*
  • Rectum / surgery*
  • Retrospective Studies
  • Treatment Outcome