A novel and facile synthesis of porous SiO2-coated ultrasmall Se particles as a drug delivery nanoplatform for efficient synergistic treatment of cancer cells

Xijian Liu; Guoying Deng; Yeying Wang; Qian Wang; Zhifang Gao; Yangang Sun; Wenlong Zhang; Jie Lu; Junqing Hu

doi:10.1039/c6nr02298g

A novel and facile synthesis of porous SiO2-coated ultrasmall Se particles as a drug delivery nanoplatform for efficient synergistic treatment of cancer cells

Nanoscale. 2016 Apr 28;8(16):8536-41. doi: 10.1039/c6nr02298g. Epub 2016 Apr 13.

Authors

Xijian Liu¹, Guoying Deng, Yeying Wang, Qian Wang, Zhifang Gao, Yangang Sun, Wenlong Zhang, Jie Lu, Junqing Hu

Affiliation

¹ College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China. liuxijian@sues.edu.cn lujie6742@sina.com.

PMID: 27072410
DOI: 10.1039/c6nr02298g

Abstract

A novel and facile synthetic route has been developed to fabricate porous SiO2-coated ultrasmall Se particles (Se@SiO2 nanospheres) as a drug delivery nanoplatform which combines Se quantum dots and doxorubicin (DOX) for efficient synergistic treatment of cancer cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / administration & dosage
Doxorubicin / administration & dosage
Drug Carriers / administration & dosage
Drug Carriers / chemistry*
Drug Delivery Systems*
HeLa Cells
Humans
Nanocomposites / administration & dosage
Nanocomposites / chemistry
Nanocomposites / ultrastructure
Nanospheres / administration & dosage
Nanospheres / chemistry*
Nanospheres / ultrastructure
Nanotechnology
Porosity
Quantum Dots / administration & dosage
Quantum Dots / chemistry
Quantum Dots / ultrastructure
Selenium / administration & dosage
Selenium / chemistry*
Silicon Dioxide

Substances

Antineoplastic Agents
Drug Carriers
Silicon Dioxide
Doxorubicin
Selenium