Abstract
Diabetes mellitus is an endocrine and metabolic disease characterized by high blood glucose. Diabetic nephropathy (DN) is one of the most typical diabetic complications. Cornus officinalis is a type of traditional Chinese medicine that replenishes the liver and kidney. Morroniside is one of the main characteristic components of C. officinalis. In this study, an in vitro model for simulating DN damage was established by stimulating rat glomerular mesangial cells by the advanced glycation end products. The protective mechanism and effect of morroniside in regulating receptor for advanced glycation end products signaling pathway in DN was investigated to provide experimental evidence for the prevention and treatment of DN.
Keywords:
AGE–RAGE pathway; Diabetic nephropathy; Glomerular mesangial cells; Morroniside.
MeSH terms
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Animals
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Cells, Cultured
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Cornus / chemistry
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Diabetic Nephropathies / drug therapy
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Diabetic Nephropathies / genetics
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Diabetic Nephropathies / prevention & control
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Down-Regulation / drug effects
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Gene Expression / drug effects*
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Glycation End Products, Advanced / adverse effects*
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Glycosides / isolation & purification
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Glycosides / pharmacology*
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Humans
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Mesangial Cells / drug effects*
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Mesangial Cells / pathology*
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NF-kappa B / genetics
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NF-kappa B / metabolism
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NF-kappa B / physiology
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Phytotherapy
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Rats
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Receptor for Advanced Glycation End Products* / genetics
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Receptor for Advanced Glycation End Products* / metabolism
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Signal Transduction*
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Transforming Growth Factor beta / genetics
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Transforming Growth Factor beta / metabolism
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Transforming Growth Factor beta / physiology
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p38 Mitogen-Activated Protein Kinases / genetics
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p38 Mitogen-Activated Protein Kinases / metabolism
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p38 Mitogen-Activated Protein Kinases / physiology
Substances
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Ager protein, rat
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Glycation End Products, Advanced
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Glycosides
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NF-kappa B
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Receptor for Advanced Glycation End Products
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Transforming Growth Factor beta
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morroniside
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p38 Mitogen-Activated Protein Kinases