The Progressively Lowered Stress Threshold (PLST) is a conceptual model for reducing behavioral symptoms in individuals with dementia. The aim of the current study was to evaluate the effectiveness of the PLST-based intervention on burden, symptoms of depression, and quality of life (QOL) of caregivers, as well as neuropsychiatric symptoms and QOL of individuals with dementia. A randomized controlled trial was used. Sixty-five participants completed the study. Although variables examined in caregivers in the intervention group showed statistically significant improvement throughout follow up, there was no statistically significant difference between the intervention and comparison groups. In addition, no statistically significant difference was noted between groups for patient variables. Care based on the PLST model was clinically effective in decreasing caregiver burden and depression of family members, and in increasing their QOL, but no more effective than routine care. [Journal of Gerontological Nursing, 42(7), 44-54.].
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