Aim: To investigate the acquisition of Mycobacterium abscessus among ventilator-dependent patients.
Materials & methods: We prospectively recruited ventilator-dependent patients in five respiratory care wards (RCWs). Respiratory specimens were cultured for mycobacteria on day 1 (D1), 3 months (M3) and 6 months (M6) after enrollment.
Results: 72 patients had cultures taken at all three time points. The proportion of patients with a culture positive for M. abscessus increased from 15.3% (11/72) on D1 to 30.6% (22/72) at M3 and 38.9% (28/72) at M6. Two M. abscessus subspecies abscessus isolates obtained from different patients had identical randomly amplified polymorphic DNA patterns. Being in RCW D and advanced age were significantly associated with initial cultures positivity.
Conclusion: Our study reveals that acquisition of M. abscessus was common among ventilator-dependent patients.
Keywords: M. abscessus; M. abscessus subspecies abscessus; M. abscessus subspecies massiliense; Taiwan; chronic respiratory care wards; dendrogram; nontuberculous mycobacteria; ventilator-dependent patients.