Applying the Airbrakes: Treating Mitochondrial Disease with Hypoxia

Oliver M Russell; Robert N Lightowlers; Doug M Turnbull

doi:10.1016/j.molcel.2016.03.027

Applying the Airbrakes: Treating Mitochondrial Disease with Hypoxia

Mol Cell. 2016 Apr 7;62(1):5-6. doi: 10.1016/j.molcel.2016.03.027.

Authors

Oliver M Russell¹, Robert N Lightowlers¹, Doug M Turnbull²

Affiliations

¹ Wellcome Trust Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
² Wellcome Trust Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. Electronic address: doug.turnbull@newcastle.ac.uk.

PMID: 27058784
DOI: 10.1016/j.molcel.2016.03.027

Abstract

A paper from Jain et al. (2016) using whole-genome CRISPR knockout libraries in human cells and models of mitochondrial disease suggests chronic hypoxia could be an unexpected treatment for disorders of mitochondrial respiration.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Humans
Leigh Disease / genetics*
Leigh Disease / therapy*
Mitochondria / metabolism*
Oxygen / metabolism*
Von Hippel-Lindau Tumor Suppressor Protein / genetics*

Substances

Von Hippel-Lindau Tumor Suppressor Protein
Oxygen

Abstract

Publication types

MeSH terms

Substances

Grants and funding