Antioxidant, antitumor and immunomodulatory activities of water-soluble polysaccharides in Abrus cantoniensis

Shaowei Wu; Xiong Fu; Lijun You; Arshad Mehmood Abbasi; Hecheng Meng; Dong Liu; Rana Muhammad Aadil

doi:10.1016/j.ijbiomac.2016.04.005

Antioxidant, antitumor and immunomodulatory activities of water-soluble polysaccharides in Abrus cantoniensis

Int J Biol Macromol. 2016 Aug:89:707-16. doi: 10.1016/j.ijbiomac.2016.04.005. Epub 2016 Apr 4.

Authors

Shaowei Wu¹, Xiong Fu¹, Lijun You¹, Arshad Mehmood Abbasi², Hecheng Meng³, Dong Liu⁴, Rana Muhammad Aadil⁵

Affiliations

¹ School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
² School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Department of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
³ School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China. Electronic address: femenghc@scut.edu.cn.
⁴ School of Applied Chemistry and Biological Technology, Shenzhen Polytechnic, Shenzhen 518055, China. Electronic address: liudongszpt@163.com.
⁵ School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; National Institute of Food Science and Technology, University of Agriculture, Faisalabad 38000, Pakistan.

PMID: 27057623
DOI: 10.1016/j.ijbiomac.2016.04.005

Abstract

Abrus cantoniensis is a vegetative food in tropical areas of Asia and claimed as folk beverages and soups consumed for cleansing liver toxicants and preventing liver diseases. Polysaccharides (ACP-І and ACP-II) were extracted with hot water from A. cantoniensis, and isolated by DEAE cellulose chromatography. The chemical properties as well as antioxidant, antitumor and immunomodulatory activities of ACP-I and ACP-II were investigated. The results showed that the ACP-I (9.09kDa) contained only glucose and ACP-II (38.45kDa) consisted of rhamnose, arabinose, galactose and glucose. ACP-II exhibited higher oxygen radical absorbance capacity (ORAC) and hydroxyl radical prevention capacity (HRPC) than ACP-I with ORAC values and HRPC values of 53.42±3.32μmol Trolox equiv./g DW and 34.84±5.07μmol Trolox equiv./g DW. Besides, in the wound healing assay, ACP-II exhibited potent migration inhibitory effects on MCF-7 cells. ACP-II could also significantly stimulate the proliferation of splenocytes and thymocytes, and enhanced NO production of peritoneal macrophages. These findings suggest that the polysaccharide ACP-II in A. cantoniensis could be served as a novel potential functional food.

Keywords: Abrus cantoniensis; Antitumor; Immunomodulatory; Polysaccharides.

MeSH terms

Abrus / chemistry*
Antineoplastic Agents / administration & dosage*
Antineoplastic Agents / chemistry
Antioxidants / administration & dosage*
Antioxidants / chemistry
Breast Neoplasms / drug therapy
Female
Humans
Immunologic Factors / administration & dosage
Immunologic Factors / chemistry
MCF-7 Cells
Plant Extracts / administration & dosage*
Plant Extracts / chemistry

Substances

Antineoplastic Agents
Antioxidants
Immunologic Factors
Plant Extracts