[Epigenetics in allergic diseases and asthma]

Abstract

Allergic diseases and asthma are the result of complex interactions between genetic predisposition and environmental factors. Asthma is one of the most prevalent chronic disease among children. In this article we review some environmental factors like: allergen exposition, tobacco, bacteria, microbial components, diet, obesity and stress, which influences during intrauterine and infancy life in the epigenetic regulation of asthma and allergic diseases. The review has been done in three models: in-vitro, animal and human.

Keywords: Allergic diseases; Asma; Asthma; Children; Enfermedades alérgicas; Environmental factors; Epigenetic; Epigenética; Factores ambientales; In-utero; Niños.