Membrane Lipids in Presynaptic Function and Disease

Neuron. 2016 Apr 6;90(1):11-25. doi: 10.1016/j.neuron.2016.02.033.

Abstract

Lipids are the most abundant organic compounds in the brain. The brain has a unique lipidome, and changes in lipid concentration, organization, and metabolism are associated with many neuronal diseases. Here, we discuss recent advances in understanding presynaptic membrane lipid organization, centered on illustrative examples of how the lipids themselves regulate membrane trafficking and control protein activity. This insight highlights that presynaptic terminals are membrane-remodeling machines and that cooperation between lipid and protein molecules underlies presynaptic activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bipolar Disorder / genetics
  • Bipolar Disorder / metabolism
  • Endocytosis
  • Exocytosis
  • Humans
  • Ion Channels / metabolism
  • Lipid Metabolism / genetics
  • Membrane Lipids / metabolism*
  • Membrane Proteins / metabolism*
  • Neurotransmitter Agents / metabolism*
  • Parkinson Disease / genetics
  • Parkinson Disease / metabolism
  • Phosphatidylinositols / metabolism
  • Presynaptic Terminals / metabolism*
  • Protein Transport*
  • SNARE Proteins / metabolism
  • Schizophrenia / genetics
  • Schizophrenia / metabolism
  • Synaptic Transmission*
  • Synaptic Vesicles / metabolism*

Substances

  • Ion Channels
  • Membrane Lipids
  • Membrane Proteins
  • Neurotransmitter Agents
  • Phosphatidylinositols
  • SNARE Proteins