Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models

Judith R Homberg; Evan J Kyzar; Michael Nguyen; William H Norton; Julian Pittman; Manoj K Poudel; Siddharth Gaikwad; Shun Nakamura; Mamiko Koshiba; Hideo Yamanouchi; Maria Luisa Scattoni; Jeremy F P Ullman; David M Diamond; Aleksandra A Kaluyeva; Matthew O Parker; Victor M Klimenko; Sergey A Apryatin; Richard E Brown; Cai Song; Raul R Gainetdinov; Irving I Gottesman; Allan V Kalueff

doi:10.1016/j.neubiorev.2016.03.013

Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models

Neurosci Biobehav Rev. 2016 Jun:65:292-312. doi: 10.1016/j.neubiorev.2016.03.013. Epub 2016 Apr 2.

Authors

Judith R Homberg¹, Evan J Kyzar², Michael Nguyen³, William H Norton⁴, Julian Pittman⁵, Manoj K Poudel⁶, Siddharth Gaikwad⁶, Shun Nakamura⁷, Mamiko Koshiba⁸, Hideo Yamanouchi⁸, Maria Luisa Scattoni⁹, Jeremy F P Ullman¹⁰, David M Diamond¹¹, Aleksandra A Kaluyeva⁶, Matthew O Parker¹², Victor M Klimenko¹³, Sergey A Apryatin¹⁴, Richard E Brown¹⁵, Cai Song¹⁶, Raul R Gainetdinov¹⁷, Irving I Gottesman¹⁸, Allan V Kalueff¹⁹

Affiliations

¹ Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands.
² Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA; The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
³ The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA; New York University School of Medicine, NY, NY, USA.
⁴ Department of Biology, University of Leicester, Leicester, UK.
⁵ Department of Biological and Environmental Sciences, Troy University, Troy, AL, USA.
⁶ The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
⁷ Tokyo University of Agriculture and Technology, Tokyo, Japan.
⁸ Departments of Pediatrics and Biochemistry, Saitama Medical University, Saitama, Japan.
⁹ Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy.
¹⁰ Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.
¹¹ Department of Psychology, University of South Florida, Tampa, FL, USA; J.A. Haley Veterans Hospital, Research and Development Service, Tampa, FL, USA.
¹² School of Health Sciences and Social Work, University of Portsmouth, Portsmouth, UK.
¹³ Pavlov Physiology Department, Institute of Experimental Medicine IEM RAS, St. Petersburg, Russia.
¹⁴ Research Institute of Nutrition RAS, Moscow, Russia.
¹⁵ Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.
¹⁶ Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada; Research Institute of Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong, China; Graduate Neuroscience Institute, China Medical University Hospital, Taichung, Taiwan.
¹⁷ Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Skolkovo Institute of Science and Technology, Skolkovo, Moscow Region, Russia.
¹⁸ Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
¹⁹ Research Institute of Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong, China; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Institutes of Chemical Technology and Natural Sciences, Ural Federal University, Ekaterinburg, Russia. Electronic address: avkalueff@gmail.com.

PMID: 27048961
DOI: 10.1016/j.neubiorev.2016.03.013

Abstract

Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy.

Keywords: Experimental model; Model organism; Neurodevelopmental disorder; Preclinical study; Translational research.

Publication types

Review

MeSH terms

Animals
Autism Spectrum Disorder
Autistic Disorder*
Brain
Neurodevelopmental Disorders*
Neurogenesis