Krebs Cycle Moonlights in Caspase Regulation

Dev Cell. 2016 Apr 4;37(1):1-2. doi: 10.1016/j.devcel.2016.03.016.

Abstract

In this issue of Developmental Cell, Aram et al. (2016) identify a mechanism that uses a Krebs cycle protein to control local activation of a ubiquitin ligase complex at the mitochondrial outer membrane for temporally and spatially restricted caspase activation during Drosophila sperm differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Caspases / metabolism*
  • Citric Acid Cycle / physiology*
  • Cullin Proteins / metabolism*
  • Drosophila / metabolism*
  • Drosophila Proteins / metabolism*
  • Male
  • Mitochondria / metabolism*
  • Spermatids / metabolism*

Substances

  • Cullin Proteins
  • Drosophila Proteins
  • Caspases