Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines

Gheorghe Roman; Valentin Năstasă; Andra-Cristina Bostănaru; Mihai Mareş

doi:10.1016/j.bmcl.2016.03.098

Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines

Bioorg Med Chem Lett. 2016 May 15;26(10):2498-2502. doi: 10.1016/j.bmcl.2016.03.098. Epub 2016 Mar 28.

Authors

Gheorghe Roman¹, Valentin Năstasă², Andra-Cristina Bostănaru², Mihai Mareş²

Affiliations

¹ Petru Poni Institute of Macromolecular Chemistry, 41A Aleea Gr. Ghica Vodă, Iaşi 700487, Romania. Electronic address: gheorghe.roman@icmpp.ro.
² Ion Ionescu de la Brad University, Laboratory of Antimicrobial Chemotherapy, 8 Aleea Sadoveanu, Iaşi 700489, Romania.

PMID: 27040660
DOI: 10.1016/j.bmcl.2016.03.098

Abstract

A small library of 1-aminoalkyl 2-naphthols has been synthesized through the direct Mannich reaction of 2-naphthols with (hetero)aromatic aldehydes and secondary amines. All of the Mannich bases having a thiophen-2-yl ring in their structure had good activity against Gram-positive bacteria, irrespective of the nature of the amino moiety.

Keywords: Aminomethylation; Antibacterial; MRSA; Mannich base; Thiophene.

MeSH terms

Aldehydes / chemistry
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology*
Drug Evaluation, Preclinical
Gram-Positive Bacteria / drug effects
Mannich Bases / chemistry*
Microbial Sensitivity Tests
Naphthols / chemistry
Small Molecule Libraries / chemistry
Small Molecule Libraries / pharmacology
Structure-Activity Relationship*

Substances

Aldehydes
Anti-Bacterial Agents
Mannich Bases
Naphthols
Small Molecule Libraries
2-naphthol