Tacky cyclic olefin copolymer: a biocompatible bonding technique for the fabrication of microfluidic channels in COC

Lab Chip. 2016 Apr 26;16(9):1561-4. doi: 10.1039/c5lc01498k.

Abstract

Cyclic olefin copolymer (COC) is widely used in microfluidics due to its UV-transparency, its biocompatibility and high chemical resistance. Here we present a fast and cost-effective solvent bonding technique, which allows for the efficient bonding of protein-patterned COC structures. The bonding process is carried out at room temperature and takes less than three minutes. Enzyme activity is retained upon bonding and microstructure deformation does not occur.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetone / chemistry
  • Adhesiveness
  • Biocompatible Materials / chemistry*
  • Cyclohexanes / chemistry
  • Cycloparaffins / chemistry
  • Enzyme Stability
  • Enzymes, Immobilized / chemistry
  • Enzymes, Immobilized / metabolism*
  • Heptanes / chemistry
  • Horseradish Peroxidase / chemistry
  • Horseradish Peroxidase / metabolism
  • Lab-On-A-Chip Devices*
  • Microtechnology / methods*
  • Models, Biological*
  • Solvents / chemistry*
  • Surface Properties
  • Toluene / chemistry

Substances

  • Biocompatible Materials
  • Cyclohexanes
  • Cycloparaffins
  • Enzymes, Immobilized
  • Heptanes
  • Solvents
  • Acetone
  • Toluene
  • n-heptane
  • Cyclohexane
  • Horseradish Peroxidase