Influence of the separation procedure on the properties of magnetic nanoparticles: Gaining in vitro stability and T1-T2 magnetic resonance imaging performance

Noelia Guldris; Bárbara Argibay; Yury V Kolen'ko; Enrique Carbó-Argibay; Tomás Sobrino; Francisco Campos; Laura M Salonen; Manuel Bañobre-López; José Castillo; José Rivas

doi:10.1016/j.jcis.2016.03.040

Influence of the separation procedure on the properties of magnetic nanoparticles: Gaining in vitro stability and T1-T2 magnetic resonance imaging performance

J Colloid Interface Sci. 2016 Jun 15:472:229-36. doi: 10.1016/j.jcis.2016.03.040. Epub 2016 Mar 19.

Affiliations

¹ International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal; Department of Applied Physics, Technological Research Institute, Nanotechnology and Magnetism Lab, Universidade de Santiago de Compostela, Spain.
² Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Spain.
³ International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal.
⁴ International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal; Department of Applied Physics, Technological Research Institute, Nanotechnology and Magnetism Lab, Universidade de Santiago de Compostela, Spain. Electronic address: jose.rivas@usc.es.

PMID: 27038785
DOI: 10.1016/j.jcis.2016.03.040

Abstract

Ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs) coated with polyacrylic acid (PAA) were synthesized by a hydrothermal method in gram-scale quantity and extensively characterized. Only the nanoparticles subjected to an additional centrifugation step showed narrow size distribution, high polymeric coverage, and ideal superparamagnetism. In addition to improved physico-chemical properties, these nanoparticles feature high stability in vitro as well as dual T1-T2 performance as contrast agents (CAs) for magnetic resonance imaging (MRI), highlighting the importance of the additional separation step in obtaining material with the desired properties.

Keywords: Contrast agent; Magnetic resonance imaging; Physico-chemical properties; Protein adsorption; Superparamagnetic iron oxide nanoparticles; T(1)–T(2) contrast.

Publication types

Research Support, Non-U.S. Gov't