Transgenic Mouse Models of SV40-Induced Cancer

Amanda L Hudson; Emily K Colvin

doi:10.1093/ilar/ilw001

Transgenic Mouse Models of SV40-Induced Cancer

ILAR J. 2016;57(1):44-54. doi: 10.1093/ilar/ilw001.

Authors

Amanda L Hudson¹, Emily K Colvin¹

Affiliation

¹ Amanda L. Hudson, PhD, is a Sydney Neuro-Oncology Group postdoctoral fellow at the Bill Walsh Translational Cancer Research Laboratory, Kolling Institute, Northern Sydney Local Health District, Sydney Medical School Northern, University of Sydney, St. Leonards, NSW, Australia. Emily K. Colvin is a Cancer Institute NSW postdoctoral fellow at the Bill Walsh Translational Cancer Research Laboratory, Kolling Institute, Northern Sydney Local Health District, Sydney Medical School Northern, University of Sydney, St. Leonards, NSW, Australia.

PMID: 27034394
DOI: 10.1093/ilar/ilw001

Abstract

The SV40 viral oncogene has been used since the 1970s as a reliable and reproducible method to generate transgenic mouse models. This seminal discovery has taught us an immense amount about how tumorigenesis occurs, and its success has led to the evolution of many mouse models of cancer. Despite the development of more modern and targeted approaches for developing genetically engineered mouse models of cancer, SV40-induced mouse models still remain frequently used today. This review discusses a number of cancer types in which SV40 mouse models of cancer have been developed and highlights their relevance and importance to preclinical research.

Keywords: SV40; cancer; mouse model; transgenic.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Mice
Mice, Transgenic*
Neoplasms / virology*
Simian virus 40 / physiology