Options in Prophylactic Surgery to Prevent Ovarian Cancer in High-Risk Women: How New Hypotheses of Fallopian Tube Origin Influence Recommendations

Casey L Swanson; Jamie N Bakkum-Gamez

doi:10.1007/s11864-016-0396-2

Options in Prophylactic Surgery to Prevent Ovarian Cancer in High-Risk Women: How New Hypotheses of Fallopian Tube Origin Influence Recommendations

Curr Treat Options Oncol. 2016 May;17(5):20. doi: 10.1007/s11864-016-0396-2.

Authors

Casey L Swanson¹, Jamie N Bakkum-Gamez²

Affiliations

¹ Department of Obstetrics and Gynecology, Division of Gynecologic Surgery, Mayo Clinic, Eisenberg Lobby 71, 200 First Street SW, Rochester, MN, 55905, USA.
² Department of Obstetrics and Gynecology, Division of Gynecologic Surgery, Mayo Clinic, Eisenberg Lobby 71, 200 First Street SW, Rochester, MN, 55905, USA. bakkum.jamie@mayo.edu.

PMID: 27032642
DOI: 10.1007/s11864-016-0396-2

Abstract

In women at increased risk of developing ovarian cancer, risk-reducing salpingo-oophorectomy is the only intervention that has been shown to decrease mortality from ovarian cancer and is the standard of care for risk reduction. Prophylactic salpingectomy with delayed oophorectomy should be considered in high-risk premenopausal women in the setting of a clinical trial.

Keywords: BRCA; Fimbriectomy; Hereditary breast and ovarian cancer syndrome; Oophorectomy; Ovarian cancer; Salpingectomy.

Publication types

Review

MeSH terms

Fallopian Tubes / surgery*
Female
Humans
Ovarian Neoplasms / prevention & control*
Ovariectomy
Premenopause
Risk Factors
Sterilization, Tubal