Gelation Behavior of 5-Chloro-8-hydroxyquinoline, an Antituberculosis Agent in Aqueous Alcohol Solutions

Erkki Kolehmainen; Hannu Salo; Jukka Korpela

doi:10.3390/antibiotics1010017

Gelation Behavior of 5-Chloro-8-hydroxyquinoline, an Antituberculosis Agent in Aqueous Alcohol Solutions

Antibiotics (Basel). 2012 Sep 19;1(1):17-24. doi: 10.3390/antibiotics1010017.

Authors

Erkki Kolehmainen¹, Hannu Salo², Jukka Korpela³

Affiliations

¹ Department of Chemistry, University of Jyväskylä, P.O. Box 35, FIN-40014 Jyväskylä, Finland. erkki.t.kolehmainen@jyu.fi.
² Department of Chemistry, University of Jyväskylä, P.O. Box 35, FIN-40014 Jyväskylä, Finland. hannu.t.salo@jyu.fi.
³ Department of Chemistry, University of Jyväskylä, P.O. Box 35, FIN-40014 Jyväskylä, Finland. jukka.p.korpela@jyu.fi.

Abstract

It was shown that 5-chloro-8-hydroxyquinoline, an antituberculosis agent, gels aqueous alcohol solutions efficiently. Thermal stability and gel-to-sol transition temperature of 1% gel in CD₃OD/D₂O (2:1) was studied by ¹H-NMR. Fibrous structures of four xerogels have been characterized by scanning electron microscope.

Keywords: 5-chloro-8-hydroxyquinoline; Mycobacterium tuberculosis; gel.