Two novel resin glycosides isolated from Ipomoea cairica with α-glucosidase inhibitory activity

Chin J Nat Med. 2016 Mar;14(3):227-31. doi: 10.1016/S1875-5364(16)30020-6.

Abstract

In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have α-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such as 1D- and 2D-NMR and HR-TOF-MS, and chemical methods. Compounds 1 and 2, named cairicoside A and cairicoside B, were evaluated for α-glucosidase inhibitory activity by the MTT method, with the IC50 values being 25.3 ± 1.6 and 28.5 ± 3.3 μmol·L(-1), respectively.

Keywords: Ipomoea cairica; Resin glycoside; Simonic acid A; α-Glucosidase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Glycoside Hydrolase Inhibitors / isolation & purification
  • Glycoside Hydrolase Inhibitors / pharmacology*
  • Ipomoea / chemistry*
  • Molecular Structure
  • Plant Extracts / pharmacology*
  • Resins, Plant / isolation & purification
  • Resins, Plant / pharmacology*
  • Spectrum Analysis
  • alpha-Glucosidases

Substances

  • Glycoside Hydrolase Inhibitors
  • Plant Extracts
  • Resins, Plant
  • alpha-Glucosidases