Corticosterone Induces Rapid Increase in the Amplitude of Inhibitory Response in Hippocampal Synapses with Asynchronous GABA Release

Bull Exp Biol Med. 2016 Mar;160(5):628-31. doi: 10.1007/s10517-016-3234-4. Epub 2016 Mar 29.

Abstract

Experiments were performed on cultured slices of rat ventral hippocampus. Using extracellular stimulation and patch clamp recording from pyramidal neurons in the hippocampal CA1 area, we studied characteristics of GABAergic synapse formed on these neurons by cholecystokinin-expressing interneurons. This synapse was characterized by asynchronous release of GABA and depolarization-induced suppression of inhibitory response. It was observed that administration of corticosterone increased the amplitude of evoked inhibitory postsynaptic currents in 5 minutes, but the paired ratio did not significantly change. Obtained data reflect that corticosterone can induce rapid genome-independent effects on inhibitory neurotransmission in one of hippocampal synapses.

Keywords: asynchronous release; corticosterone, GABA; hippocampus; interneuron.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects*
  • Animals
  • Cholecystokinin / biosynthesis
  • Corticosterone / pharmacology*
  • Electric Stimulation
  • Evoked Potentials / drug effects*
  • GABAergic Neurons / metabolism*
  • Hippocampus / drug effects*
  • Hippocampus / physiology
  • Interneurons / metabolism
  • Patch-Clamp Techniques
  • Pyramidal Cells / physiology
  • Rats
  • Rats, Wistar
  • Synapses / drug effects
  • Synaptic Transmission / drug effects*
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • gamma-Aminobutyric Acid
  • Cholecystokinin
  • Corticosterone