Abstract
In mammals, metabolic adaptations are required to overcome nutritional deprivation in amino-acids/proteins as well as episodes of malnutrition. GCN2 protein kinase, which phosphorylates the α subunit of the translation initiation factor eIF2, is a sensor of amino-acid(s) deficiencies. On one hand, this review briefly describes the main features of amino-acid metabolism. On the other hand, it describes the role of GCN2 in regulating numerous physiological functions.
© Société de Biologie, 2016.
MeSH terms
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Adaptation, Biological / physiology*
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Amino Acids
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Amino Acids, Essential / administration & dosage*
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Amino Acids, Essential / deficiency
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Animals
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Diet*
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Eukaryotic Initiation Factor-2 / metabolism
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Homeostasis
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Humans
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Immunity
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Malnutrition
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Neuronal Plasticity
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Nutritional Status
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Phosphorylation
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Protein Serine-Threonine Kinases / physiology*
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Signal Transduction / physiology
Substances
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Amino Acids
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Amino Acids, Essential
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Eukaryotic Initiation Factor-2
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EIF2AK4 protein, human
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Protein Serine-Threonine Kinases