Preparation and characterization of the pH and thermosensitive magnetic molecular imprinted nanoparticle polymer for the cancer drug delivery

Bioorg Med Chem Lett. 2016 May 1;26(9):2349-54. doi: 10.1016/j.bmcl.2016.03.020. Epub 2016 Mar 8.

Abstract

A novel pH and thermosensitive magnetic nanoparticle polymer composite [poly(NIPAAM@Fe3O4 MNPs/TMSPMC/DOX)] was synthesized by radical polymerization of N-isopropylacrylamide (NIPAAM) and the methacrylate functionalized Fe3O4 nanoparticles/DOX complex using AIBN and EGDMA, and used as a drug carrier for the DOX drug delivery. Formation of poly(NIPAAM@Fe3O4 MNPs/TMSPMC/DOX) was confirmed by FTIR, XRD, UV-Vis, VSM, TGA-DTA and SEM. The results showed the high DOX loading controls release. Moreover, it showed the lower critical solution temperature of 40°C which can be beneficial in cancer drug delivery, since the temperature of cancer cells is higher than normal ones, and DOX can be released selectively in cancer cells.

Keywords: Cancer drug delivery; Doxorubicin; Fe(3)O(4) magnetic nanoparticles; pH and thermosensitive composite.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Drug Delivery Systems*
  • Hydrogen-Ion Concentration*
  • Molecular Imprinting*
  • Nanoparticles*
  • Polymers / administration & dosage*
  • Spectrum Analysis / methods
  • Temperature
  • X-Ray Diffraction

Substances

  • Antineoplastic Agents
  • Polymers