Hepatic Perfusion Therapy

Rahul Rajeev; T Clark Gamblin; Kiran K Turaga

doi:10.1016/j.suc.2015.12.005

Hepatic Perfusion Therapy

Surg Clin North Am. 2016 Apr;96(2):357-68. doi: 10.1016/j.suc.2015.12.005.

Authors

Rahul Rajeev¹, T Clark Gamblin¹, Kiran K Turaga²

Affiliations

¹ Division of Surgical Oncology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA.
² Division of Surgical Oncology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA. Electronic address: kturaga@mcw.edu.

PMID: 27017869
DOI: 10.1016/j.suc.2015.12.005

Abstract

Isolated hepatic perfusion uses the unique vascular supply of hepatic malignancies to deliver cytotoxic chemotherapy. The procedure involves vascular isolation of the liver and delivery of chemotherapy via the hepatic artery and extraction from retrohepatic vena cava. Benefits of hepatic perfusion have been observed in hepatic metastases of ocular melanoma and colorectal cancer and primary hepatocellular carcinoma. Percutaneous and prophylactic perfusions are avenues of ongoing research.

Keywords: Colorectal cancer; Hepatic metastases; Hepatocellular carcinoma; Isolated hepatic perfusion; Melanoma; Percutaneous hepatic perfusion; Regional therapies.

Publication types

Review

MeSH terms

Chemotherapy, Cancer, Regional Perfusion* / methods
Humans
Liver Neoplasms / drug therapy*
Patient Selection