[COMBINATION OF TAURINE WITH ZINC DIASPARTATE FOR CORRECTION OF METABOLISM DISTURBANSES IN NEPHRONS AND RENAL FUNCTION IN RATS WITH CONTRAST-INDUCED NEPHROPATHY]

Eksp Klin Farmakol. 2015;78(11):12-4.
[Article in Russian]

Abstract

The nephroprotective properties of a combination of taurine with zinc diaspartate (taucin) in rats with contrast-induced nephropathy have been estimated. It is established that the combination of taurine with zinc diaspartate (20 and 1 g/mol, respectively, ingested in doses 250 and 500 mg/kg in the stomach during 14 days) produces a dose-dependent nephroprotective action on rats with contrast-induced (sodium and meglumin amidotrizoates, 800 mg/kg/day intraperitoneally, 14 days) nephropathy.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Aspartic Acid / pharmacology*
  • Kidney Diseases / drug therapy*
  • Kidney Diseases / etiology
  • Kidney Diseases / metabolism*
  • Kidney Diseases / pathology
  • Male
  • Nephrons / metabolism*
  • Nephrons / pathology
  • Rats
  • Taurine / pharmacology*
  • Zinc / pharmacology*

Substances

  • Taurine
  • Aspartic Acid
  • Zinc