Abstract
This work describes the anti-inflammatory effect of the curcumin-analog compound, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate (DM1), and shows that DM1 modulates iNOS and COX-2 gene expression in cultured RAW 264.7 cells and induces autophagy on human melanoma cell line A375.
Keywords:
Anti-inflammatory; Autophagy; COX-2; Curcumin analog; DM1; Edema; Peritonitis; iNOS.
Copyright © 2016 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Autophagy / drug effects*
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Carrageenan
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Cells, Cultured
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Curcumin / analogs & derivatives*
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Curcumin / chemistry
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Curcumin / pharmacology*
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Cyclooxygenase 2 / genetics*
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Dose-Response Relationship, Drug
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Edema / chemically induced
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Edema / drug therapy*
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Gene Expression Profiling
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Gene Expression Regulation, Enzymologic / drug effects*
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Humans
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Male
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Mice
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Molecular Structure
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Nitric Oxide / biosynthesis
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Nitric Oxide Synthase Type II / genetics*
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Structure-Activity Relationship
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Nitric Oxide
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Carrageenan
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Nitric Oxide Synthase Type II
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Nos2 protein, mouse
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Ptgs2 protein, mouse
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Cyclooxygenase 2
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Curcumin