A Practical Guide to The Cancer Genome Atlas (TCGA)

Zhining Wang; Mark A Jensen; Jean Claude Zenklusen

doi:10.1007/978-1-4939-3578-9_6

A Practical Guide to The Cancer Genome Atlas (TCGA)

Methods Mol Biol. 2016:1418:111-41. doi: 10.1007/978-1-4939-3578-9_6.

Authors

Zhining Wang¹, Mark A Jensen², Jean Claude Zenklusen³

Affiliations

¹ Center for Cancer Genomics, National Cancer Institute, National Institutes of Health, 31 Center Drive, Bethesda, MD, USA. zhining.wang@nih.gov.
² Research Administration Directorate, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, 8560 Progress Drive, Frederick, 21701, MD, USA.
³ Center for Cancer Genomics, National Cancer Institute, National Institutes of Health, 31 Center Drive, Bethesda, MD, USA.

PMID: 27008012
DOI: 10.1007/978-1-4939-3578-9_6

Abstract

The Cancer Genome Atlas (TCGA) is one of the most ambitious and successful cancer genomics programs to date. The TCGA program has generated, analyzed, and made available genomic sequence, expression, methylation, and copy number variation data on over 11,000 individuals who represent over 30 different types of cancer. This chapter provides a brief overview of the TCGA program and detailed instructions and tips for investigators on how to find, access, and download this data.

Keywords: Cancer genomics; Copy number; Methylation; Mutation; Next-generation sequencing; Proteomics; TCGA; The Cancer Genome Atlas; Transcriptome; miRNA.

MeSH terms

Animals
Computational Biology / methods*
Databases, Genetic*
Genomics / methods*
Humans
Neoplasms / genetics*
Neoplasms / metabolism
Software
Web Browser