Design of a hydrophobic tripeptide that self-assembles into amphiphilic superstructures forming a hydrogel biomaterial

A V Vargiu; D Iglesias; K E Styan; L J Waddington; C D Easton; S Marchesan

doi:10.1039/c5cc10531e

Design of a hydrophobic tripeptide that self-assembles into amphiphilic superstructures forming a hydrogel biomaterial

Chem Commun (Camb). 2016 May 1;52(35):5912-5. doi: 10.1039/c5cc10531e. Epub 2016 Mar 21.

Authors

A V Vargiu¹, D Iglesias, K E Styan, L J Waddington, C D Easton, S Marchesan

Affiliation

¹ University of Cagliari, Department of Physics, S. P. Monserrato-Sestu Km. 0.700, 09042 Monserrato, CA, Italy.

PMID: 26998534
DOI: 10.1039/c5cc10531e

Abstract

We report the rational design of a heterochiral hydrophobic tripeptide self-assembling into amphiphilic d-superstructures that yield a self-supportive hydrogel at physiological pH. The material endures cell culture conditions and sustains fibroblast proliferation. Tripeptide superstructures are thoroughly analysed by several techniques.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials / chemistry*
Biocompatible Materials / pharmacology
Cell Proliferation / drug effects
Drug Design*
Fibroblasts / cytology
Fibroblasts / drug effects
Hydrogels / chemistry*
Hydrophobic and Hydrophilic Interactions*
Molecular Dynamics Simulation
Oligopeptides / chemistry*
Oligopeptides / pharmacology
Protein Conformation, beta-Strand

Substances

Biocompatible Materials
Hydrogels
Oligopeptides