Abstract
In this study, we compared the ability of human mesenchymal stem cells derived from menstrual blood (eMSCs) and mesenchymal stem cells (MSCs) from other tissues to differentiate into decidual cells in vitro. It was demonstrated that during differentiation secretion of decidualization markers (prolactin and insulin-like growth factor binding protein-1) increases in eMSCs from adipose tissue (MSC-AD). Thus, the ability of eMSCs to differentiate into decidual cells is much higher than MSC-BM or MSC-AD. It makes eMSCs promising for application in cellular therapy of infertility associated with decidualzation insufficiency.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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8-Bromo Cyclic Adenosine Monophosphate / pharmacology
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Adipose Tissue / cytology*
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Adipose Tissue / drug effects
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Adipose Tissue / metabolism
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Antigens, CD / genetics
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Antigens, CD / metabolism
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Biomarkers / metabolism
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Bone Marrow Cells / cytology*
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Bone Marrow Cells / drug effects
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Bone Marrow Cells / metabolism
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Cell Differentiation / drug effects
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Decidua / cytology*
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Decidua / drug effects
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Decidua / metabolism
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Female
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Gene Expression
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Humans
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Insulin-Like Growth Factor Binding Protein 1 / genetics
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Insulin-Like Growth Factor Binding Protein 1 / metabolism
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Menstruation / physiology
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Mesenchymal Stem Cells / cytology*
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Mesenchymal Stem Cells / drug effects
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Mesenchymal Stem Cells / metabolism
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Primary Cell Culture
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Prolactin / genetics
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Prolactin / metabolism
Substances
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Antigens, CD
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Biomarkers
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IGFBP1 protein, human
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Insulin-Like Growth Factor Binding Protein 1
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8-Bromo Cyclic Adenosine Monophosphate
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Prolactin