Abstract
An effective vaccine for human immunodeficiency virus (HIV) is urgently needed to prevent HIV infection and progression to acquired immune deficiency syndrome (AIDS). As glycosylation of viral proteins becomes better understood, carbohydrate-based antiviral vaccines against special viruses have attracted much attention. Significant efforts in carbohydrate synthesis and immunogenicity research have resulted in the development of multiple carbohydrate-based HIV vaccines. This review summarizes recent advances in synthetic carbohydrate-based vaccines design strategies and the applications of these vaccines in the prevention of HIV.
Keywords:
N-glycosylation; glycoprotein; human immunodeficiency virus (HIV); neutralizing antibodies; vaccine.
MeSH terms
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Antibodies, Neutralizing / immunology
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Carbohydrates / chemical synthesis*
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Carbohydrates / chemistry
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Carbohydrates / immunology*
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Drug Design
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Glycoproteins / chemistry
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Glycoproteins / immunology
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HIV Antibodies / blood
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HIV Antibodies / immunology
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HIV Infections / immunology*
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HIV Infections / prevention & control
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HIV Infections / virology
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HIV-1 / chemistry
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HIV-1 / genetics
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HIV-1 / immunology*
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Humans
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Oligosaccharides / chemical synthesis
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Oligosaccharides / chemistry
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Vaccines, Subunit / chemistry
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Vaccines, Subunit / immunology
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Vaccines, Synthetic / chemistry*
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Vaccines, Synthetic / immunology*
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Viral Core Proteins / genetics
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Viral Core Proteins / immunology
Substances
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Antibodies, Neutralizing
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Carbohydrates
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Glycoproteins
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HIV Antibodies
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Oligosaccharides
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Vaccines, Subunit
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Vaccines, Synthetic
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Viral Core Proteins