Morbidity and mortality of sickle cell disease patients starting intermittent haemodialysis: a comparative cohort study with non- Sickle dialysis patients

Br J Haematol. 2016 Jul;174(1):148-52. doi: 10.1111/bjh.14040. Epub 2016 Mar 17.

Abstract

We performed a retrospective study to assess the changes in clinical, biological and heart echocardiographic parameters in 32 sickle cell disease (SCD) patients beginning haemodialysis. Acute SCD-related complications were similar at 6 months before and 6 months after the initiation of haemodialysis. Median haemoglobin level did not change significantly, but the need for blood transfusions increased (P < 0·001). The 5-year incidence of death was higher in SCD patients (P < 0·0001). The 5-year likelihood of receiving a renal graft was lower in SCD patients (P = 0·022). Our findings suggest that SCD patients have poorer survival and a lower likelihood of receiving a renal graft.

Keywords: dialysis; kidney; sickle cell disease; survival; vaso-occlusive crises.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Anemia, Sickle Cell / complications*
  • Anemia, Sickle Cell / mortality
  • Anemia, Sickle Cell / therapy
  • Blood Transfusion / statistics & numerical data
  • Cohort Studies
  • Female
  • Hemoglobins / analysis
  • Humans
  • Kidney Transplantation / statistics & numerical data
  • Male
  • Morbidity
  • Mortality
  • Renal Dialysis
  • Renal Insufficiency, Chronic / mortality
  • Renal Insufficiency, Chronic / therapy
  • Retrospective Studies
  • Young Adult

Substances

  • Hemoglobins