Antimelanogenic effect of 4-hydroxylonchocarpin through the inhibition of tyrosinase-related proteins and MAPK phosphatase

Exp Dermatol. 2016 Jul;25(7):574-6. doi: 10.1111/exd.13004.

Authors

Jihyun Lim¹, Sorim Nam¹, Hua Li², Young Yang¹, Myeong-Sok Lee¹, Hee Gu Lee³, Jae-Ha Ryu², Jong-Seok Lim¹

Affiliations

¹ Department of Biological Science and the Research Center for Women's Diseases, Sookmyung Women's University, Seoul, Korea.
² Research Center for Cell Fate Control, College of Pharmacy, Sookmyung Women's University, Seoul, Korea.
³ Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.

PMID: 26990777
DOI: 10.1111/exd.13004

No abstract available

Keywords: 4-hydroxylonchocarpin; Psoralea corylifolia; melanogenesis; microphthalmia-associated transcription factor (MITF); tyrosinase.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Drug Evaluation, Preclinical
Dual Specificity Phosphatase 1 / antagonists & inhibitors
Flavones / isolation & purification
Flavones / pharmacology
Flavones / therapeutic use*
Humans
Hyperpigmentation / drug therapy*
Melanins / metabolism*
Mice
Microphthalmia-Associated Transcription Factor / antagonists & inhibitors*
Phytotherapy
Psoralea / chemistry*
Skin Lightening Preparations / analysis

Substances

4-hydroxylonchocarpin
Flavones
Melanins
Microphthalmia-Associated Transcription Factor
Skin Lightening Preparations
Dual Specificity Phosphatase 1