Understanding How DNA Enzymes Work

Angew Chem Int Ed Engl. 2016 Apr 25;55(18):5376-7. doi: 10.1002/anie.201601175. Epub 2016 Mar 16.

Abstract

Tied up in knots: The crystal structure of a DNA enzyme in its post-catalytic state was solved. The results provide insight into the structural possibilities for DNA and the mechanism of DNA catalysis.

Keywords: 9DB1; DNA structures; DNAzymes; X-ray diffraction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalytic Domain
  • Crystallography, X-Ray
  • DNA, Catalytic / chemistry*
  • DNA, Catalytic / metabolism
  • Models, Molecular
  • Nucleic Acid Conformation
  • RNA / metabolism

Substances

  • DNA, Catalytic
  • RNA