Ecdysones from Zoanthus spp. with inhibitory activity against dengue virus 2

Bioorg Med Chem Lett. 2016 May 1;26(9):2344-8. doi: 10.1016/j.bmcl.2016.03.029. Epub 2016 Mar 9.

Abstract

Bioassay-guided fractionation of an ethanolic extract of Zoanthus spp. collected in Taiwan has resulted in the isolation of one new ecdysone, zoanthone A (1), along with thirteen known compounds (2-14). The structures of these compounds were determined by spectroscopic methods, especially 2D NMR analyses. The in vitro antiviral activities of all isolated ecdysones (1-14) against dengue virus type 2 (DENV-2) were evaluated using DENV infectious system. New compound (1) exhibited potent antiviral activity (EC50=19.61 ± 2.46 μM) with a selectivity index (CC50/EC50) value of 36.7. The structure-activity relationships of isolated ecdysones against DENV-2 were concluded. Molecular docking information of 3 and NS5 polymerase was performed either.

Keywords: Dengue virus type 2; Ecdysone; Molecular docking; Structure–activity relationships; Zoanthus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Dengue Virus / drug effects*
  • Ecdysone / chemistry
  • Ecdysone / pharmacology*
  • Structure-Activity Relationship

Substances

  • Antiviral Agents
  • Ecdysone