Recent advances in capillary electrophoretic migration techniques for pharmaceutical analysis (2013-2015)

Sami El Deeb; Hermann Wätzig; Deia Abd El-Hady; Cari Sänger-van de Griend; Gerhard K E Scriba

doi:10.1002/elps.201600058

Recent advances in capillary electrophoretic migration techniques for pharmaceutical analysis (2013-2015)

Electrophoresis. 2016 Jul;37(12):1591-608. doi: 10.1002/elps.201600058. Epub 2016 Apr 24.

Authors

Sami El Deeb¹, Hermann Wätzig¹, Deia Abd El-Hady^{2

3}, Cari Sänger-van de Griend^{4

5

6}, Gerhard K E Scriba⁷

Affiliations

¹ Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig, Braunschweig, Germany.
² Chemistry Department, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia.
³ Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt.
⁴ Kantisto BV, Baarn, The Netherlands.
⁵ Uppsala University, Department of Medicinal Chemistry, Division of Analytical Pharmaceutical Chemistry, Biomedical Centre, Uppsala, Sweden.
⁶ Australian Centre for Research on Separation Science (ACROSS), School of Chemistry, University of Tasmania, Hobart, Tasmania, Australia.
⁷ Friedrich Schiller University, School of Pharmacy, Department of Pharmaceutical/Medicinal Chemistry, Jena, Germany.

PMID: 26988029
DOI: 10.1002/elps.201600058

Abstract

This review updates and follows-up a previous review by highlighting recent advancements regarding capillary electromigration methodologies and applications in pharmaceutical analysis. General approaches such as quality by design as well as sample injection methods and detection sensitivity are discussed. The separation and analysis of drug-related substances, chiral CE, and chiral CE-MS in addition to the determination of physicochemical constants are addressed. The advantages of applying affinity capillary electrophoresis in studying receptor-ligand interactions are highlighted. Finally, current aspects related to the analysis of biopharmaceuticals are reviewed. The present review covers the literature between January 2013 and December 2015.

Keywords: Biopharmaceuticals; Capillary electrophoresis; Pharmaceutical analysis; Quantitation.

Publication types

Review

MeSH terms

Electrophoresis, Capillary / methods*
Pharmaceutical Preparations / analysis*
Protein Binding
Receptors, Cell Surface / analysis
Receptors, Cell Surface / metabolism
Stereoisomerism

Substances

Pharmaceutical Preparations
Receptors, Cell Surface