KLF4 Initiates Acinar Cell Reprogramming and Is Essential for the Early Stages of Pancreatic Carcinogenesis

Ravikanth Maddipati; Jonathan P Katz

doi:10.1016/j.ccell.2016.02.019

KLF4 Initiates Acinar Cell Reprogramming and Is Essential for the Early Stages of Pancreatic Carcinogenesis

Cancer Cell. 2016 Mar 14;29(3):247-248. doi: 10.1016/j.ccell.2016.02.019.

Authors

Ravikanth Maddipati¹, Jonathan P Katz²

Affiliations

¹ Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-4863, USA.
² Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-4863, USA. Electronic address: jpkatz@mail.med.upenn.edu.

PMID: 26977875
DOI: 10.1016/j.ccell.2016.02.019

Abstract

Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and is minimally responsive to current chemotherapies. In this issue of Cancer Cell, Xie et al. (2016) identify the transcription factor KLF4 as essential for the early stages of pancreatic carcinogenesis, expanding the repertoire of targets for early intervention strategies.

Publication types

Comment

MeSH terms

Acinar Cells / pathology*
Animals
Carcinogenesis / genetics*
Carcinogenesis / pathology*
Humans
Kruppel-Like Factor 4
Kruppel-Like Transcription Factors / metabolism*
Pancreas / pathology*
Pancreatic Ducts / pathology*
Precancerous Conditions / genetics*

Substances

KLF4 protein, human
Kruppel-Like Factor 4
Kruppel-Like Transcription Factors

Grants and funding

R01 DK069984/DK/NIDDK NIH HHS/United States