Expression of γ-Synuclein in Bladder Carcinoma: A Possible Marker for Prognosis

Anticancer Res. 2016 Mar;36(3):951-6.

Abstract

Aim: To investigate if γ-synuclein (SNCG) could be used as a bladder cancer (BC) marker to predict prognosis of BC.

Patients and methods: Medical records of 140 patients with BC (January, 2006 to December, 2009) were retrospectively reviewed. SNCG expression level was examined by immunohistological staining. The patients' survival rate was calculated by the Kaplan-Meier method. Cox proportional regression model was used to identify independent predictors for BC.

Results: Overexpression of SNCG was detected in BC tissues and the expression level of SNCG strongly positively correlated with BC recurrence. However, no correlation was found between SNCG level and tumor stage or survival rate.

Conclusion: SNCG is a good marker to predict recurrence of BC, but not a reliable marker for staging or prediction of survival rate.

Keywords: bladder carcinoma; prognosis; recurrence; γ-Synuclein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / metabolism
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Proteins / metabolism*
  • Neoplasm Recurrence, Local / metabolism*
  • Proportional Hazards Models
  • Survival Rate
  • Up-Regulation*
  • Urinary Bladder / metabolism*
  • Urinary Bladder / pathology
  • Young Adult
  • gamma-Synuclein / metabolism*

Substances

  • Biomarkers, Tumor
  • Neoplasm Proteins
  • SNCG protein, human
  • gamma-Synuclein