Bipolaris oryzae, a novel fungal opportunist causing keratitis

Luxia Wang; Abdullah M S Al-Hatmi; Xuwen Lai; Lianghong Peng; Chuanhong Yang; Huangwen Lai; Jianxun Li; Jacques F Meis; G Sybren de Hoog; Chao Zhuo; Min Chen

doi:10.1016/j.diagmicrobio.2015.11.020

Bipolaris oryzae, a novel fungal opportunist causing keratitis

Diagn Microbiol Infect Dis. 2016 May;85(1):61-5. doi: 10.1016/j.diagmicrobio.2015.11.020. Epub 2015 Nov 24.

Authors

Luxia Wang¹, Abdullah M S Al-Hatmi², Xuwen Lai³, Lianghong Peng⁴, Chuanhong Yang⁴, Huangwen Lai⁴, Jianxun Li¹, Jacques F Meis⁵, G Sybren de Hoog⁶, Chao Zhuo⁷, Min Chen⁸

Affiliations

¹ Laboratory Department, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
² CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands; Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands; Directorate General of Health Services, Ministry of Health, Ibri Hospital, Ibri, Oman.
³ Department of Pathology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
⁴ Department of Ophthalmology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
⁵ Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
⁶ CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands; Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands; Basic Pathology Department, Federal University of Paraná State, Curitiba, Paraná, Brazil; King Abdulaziz University, Jeddah, Saudi Arabia.
⁷ State Key Laboratory of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. Electronic address: chao_sheep@263.net.
⁸ CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands; Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands; Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Shanghai Institute of Medical Mycology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China. Electronic address: chenmin9611233@163.com.

PMID: 26976720
DOI: 10.1016/j.diagmicrobio.2015.11.020

Abstract

We report a case of mycotic keratitis caused by Bipolaris oryzae with predisposing trauma from a foreign body. The fungus was identified by sequencing the internal transcribed spacer region, translation elongation factor 1α (TEF1) gene, and partial glyceraldehyde-3-phosphate dehydrogenase (GPDH) gene, and the species identity was confirmed on the basis of its characteristic conidial phenotype. The patient was treated with surgical intervention and antifungal agents, including intravenous fluconazole (FLC), oral itraconazole, topical 0.15% amphotericin B eye drops, and 0.5% FLC eye drops. To our knowledge, this is the first report of mycotic keratitis caused by B. oryzae worldwide.

Keywords: Amphotericin B; Bipolaris oryzae; Mycotic keratitis.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Amphotericin B / administration & dosage
Amphotericin B / therapeutic use
Antifungal Agents / administration & dosage
Antifungal Agents / therapeutic use
Ascomycota* / classification
Ascomycota* / cytology
Ascomycota* / genetics
Ascomycota* / ultrastructure
Genes, Fungal
Humans
Keratitis / diagnosis*
Keratitis / drug therapy
Keratitis / microbiology*
Male
Middle Aged
Ophthalmic Solutions
Opportunistic Infections / diagnosis*
Opportunistic Infections / drug therapy
Opportunistic Infections / microbiology*
Phylogeny
Treatment Outcome

Substances

Antifungal Agents
Ophthalmic Solutions
Amphotericin B