Host genome polymorphisms and tuberculosis infection: What we have to say?

Said Alfin Khalilullah; Harapan Harapan; Nabeeh A Hasan; Wira Winardi; Ichsan Ichsan; Mulyadi Mulyadi

doi:10.1016/j.ejcdt.2013.12.002

Host genome polymorphisms and tuberculosis infection: What we have to say?

Egypt J Chest Dis Tuberc. 2014 Jan;63(1):173-185. doi: 10.1016/j.ejcdt.2013.12.002. Epub 2013 Dec 17.

Authors

Said Alfin Khalilullah¹, Harapan Harapan², Nabeeh A Hasan³, Wira Winardi⁴, Ichsan Ichsan⁵, Mulyadi Mulyadi⁶

Affiliations

¹ Medical Research Unit, School of Medicine Syiah Kuala University, Banda Aceh, Indonesia.
² Medical Research Unit, School of Medicine Syiah Kuala University, Banda Aceh, Indonesia; Tropical Disease Center, School of Medicine Syiah Kuala University, Banda Aceh, Indonesia.
³ Research Affiliate, Centre for Genes, Environment and Health, National Jewish Health, Denver, CO, USA; Computational Bioscience Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
⁴ Medical Research Unit, School of Medicine Syiah Kuala University, Banda Aceh, Indonesia; Graduate Institute of Medical Science, Taipei Medical University, Taipei, Taiwan.
⁵ Medical Research Unit, School of Medicine Syiah Kuala University, Banda Aceh, Indonesia; Tropical Disease Center, School of Medicine Syiah Kuala University, Banda Aceh, Indonesia; Institute of Medical Microbiology and National Reference Center for Systemic Mycosis, University Medical Center Goettingen, Goettingen, Germany.
⁶ Pulmonology Department, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.

Abstract

Several epidemiology studies suggest that host genetic factors play important roles in susceptibility, protection and progression of tuberculosis infection. Here we have reviewed the implications of some genetic polymorphisms in pathways related to tuberculosis susceptibility, severity and development. Large case-control studies examining single-nucleotide polymorphisms (SNPs) in genes have been performed in tuberculosis patients in some countries. Polymorphisms in natural resistance-associated macrophage protein 1 (NRAMP1), toll-like receptor 2 (TLR2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interleukin-1 receptor antagonist (IL-1RA), IL-10, vitamin D receptor (VDR), dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN), monocyte chemoattractant protein-1 (MCP-1), nucleotide oligomerization binding domain 2 (NOD2), interferon-gamma (IFN-γ), inducible nitric oxide synthase (iNOS), mannose-binding lectin (MBL) and surfactant proteins A (SP-A) have been reviewed. These genes have been variably associated with tuberculosis infection and there is strong evidence indicating that host genetic factors play critical roles in tuberculosis susceptibility, severity and development.

Keywords: Gene polymorphism; Mycobacterium tuberculosis; Tuberculosis development; Tuberculosis infection; Tuberculosis protection; Tuberculosis susceptibility.

Grants and funding

T15 LM009451/LM/NLM NIH HHS/United States