New antimalarial norterpene cyclic peroxides from Xisha Islands sponge Diacarnus megaspinorhabdosa

Bioorg Med Chem Lett. 2016 Apr 15;26(8):2084-7. doi: 10.1016/j.bmcl.2016.02.070. Epub 2016 Feb 23.

Abstract

Four new norterpene cyclic peroxides (1-4), together with three known norterpene cyclic peroxides were isolated from the Xisha Islands Sponge Diacarnus megaspinorhabdosa. Their structures were elucidated on the basis of spectroscopic analyses and comparison with the related model compounds. The compounds (1-7) were evaluated for the inhibitory activity against the malaria parasite Plasmodium falciparum, all of them showed significant antimalarial activity with IC50 values in the range of 1.6-8.6 μM.

Keywords: Antimalarial; Diacarnus megaspinorhabdosa; Norterpene cyclic peroxide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / chemical synthesis
  • Antimalarials / chemistry
  • Antimalarials / isolation & purification
  • Antimalarials / pharmacology*
  • Dose-Response Relationship, Drug
  • Molecular Structure
  • Parasitic Sensitivity Tests
  • Peroxides / chemical synthesis
  • Peroxides / chemistry
  • Peroxides / isolation & purification
  • Peroxides / pharmacology*
  • Plasmodium falciparum / drug effects*
  • Porifera / chemistry*
  • Structure-Activity Relationship

Substances

  • Antimalarials
  • Peroxides