Tracking HSC Origin: From Bench to Placenta

Vincenzo Calvanese; Hanna K A Mikkola

doi:10.1016/j.devcel.2016.02.022

Tracking HSC Origin: From Bench to Placenta

Dev Cell. 2016 Mar 7;36(5):479-80. doi: 10.1016/j.devcel.2016.02.022.

Authors

Vincenzo Calvanese¹, Hanna K A Mikkola²

Affiliations

¹ Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA.
² Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: hmikkola@mcdb.ucla.edu.

PMID: 26954540
DOI: 10.1016/j.devcel.2016.02.022

Abstract

Reporting in Developmental Cell, Pereira et al. (2016) use in vitro lineage reprogramming insights to inform understanding of hematopoietic stem cell (HSC) development in vivo. They find Prom1(+)Sca1(+)CD34(+)CD45(-) hemogenic precursors, akin to fibroblast-derived hemato-vascular precursors, in mouse placenta and embryo. The cells mature into transplantable HSCs in culture.

Publication types

Comment

MeSH terms

Animals
Cell Differentiation / physiology*
Cell Lineage / physiology*
Cellular Reprogramming*
Female
Hematopoiesis / genetics*
Hematopoietic Stem Cells / cytology*
Mouse Embryonic Stem Cells / cytology*
Pregnancy