A novel disposable electrochemical sensor for determination of carbamazepine based on Fe doped SnO2 nanoparticles modified screen-printed carbon electrode

N Lavanya; C Sekar; S Ficarra; E Tellone; A Bonavita; S G Leonardi; G Neri

doi:10.1016/j.msec.2016.01.027

A novel disposable electrochemical sensor for determination of carbamazepine based on Fe doped SnO2 nanoparticles modified screen-printed carbon electrode

Mater Sci Eng C Mater Biol Appl. 2016 May:62:53-60. doi: 10.1016/j.msec.2016.01.027. Epub 2016 Jan 13.

Authors

N Lavanya¹, C Sekar², S Ficarra³, E Tellone³, A Bonavita⁴, S G Leonardi⁴, G Neri⁴

Affiliations

¹ Department of Biosensors and Bioelectronics, Alagappa University, Karaikudi 630003, TN, India; Department of Electronic Engineering, Chemistry and Materials Engineering, University of Messina, Messina 98166, Italy.
² Department of Biosensors and Bioelectronics, Alagappa University, Karaikudi 630003, TN, India. Electronic address: Sekar2025@gmail.com.
³ Department of Chemical Sciences, University of Messina, Messina 98166, Italy.
⁴ Department of Electronic Engineering, Chemistry and Materials Engineering, University of Messina, Messina 98166, Italy.

PMID: 26952397
DOI: 10.1016/j.msec.2016.01.027

Abstract

An effective strategy to fabricate a novel disposable screen printing carbon electrode modified by iron doped tin dioxide nanoparticles for carbamazepine (CBZ) detection has been developed. Fe-SnO2 (Fe=0 to 5 wt.%) NPs were synthesized by a simple microwave irradiation method and assessed for their structural and morphological changes due to Fe doping into SnO2 matrix by X-ray diffraction and scanning and transmission electron microscopy. The electrochemical behaviour of carbamazepine at the Fe-SnO2 modified screen printed carbon electrode (SPCE) was investigated by cyclic voltammetry and square wave voltammetry. Electron transfer coefficient α (0.63) and electron transfer rate constant ks (0.69 s(-1)) values of the 5 wt.% Fe-SnO2 modified SPCE indicate that the diffusion controlled process takes place on the electrode surface. The fabricated sensor displayed a good electrooxidation response towards the detection of CBZ at a lower oxidation potential of 0.8 V in phosphate buffer solution at pH7.0. Under the optimal conditions, the sensor showed fast and sensitive current response to CBZ over a wide linear range of 0.5-100 μM with a low detection limit of 92 nM. Furthermore, the practical application of the modified electrode has been investigated by the determination of CBZ in pharmaceutical products using standard addition method.

Keywords: Carbamazepine; Fe doped SnO(2) nanoparticles; Pharmaceutical products; Square wave voltammetry.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbamazepine / analysis*
Carbamazepine / chemistry
Carbon / chemistry
Electrochemical Techniques*
Electrodes
Iron / chemistry*
Limit of Detection
Microscopy, Electron, Scanning
Nanoparticles / chemistry*
Oxidation-Reduction
Pharmaceutical Preparations / chemistry
Tin Compounds / chemistry*
X-Ray Diffraction

Substances

Pharmaceutical Preparations
Tin Compounds
Carbamazepine
Carbon
Iron
stannic oxide